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Knockout of vascular smooth muscle EGF receptor in a mouse model prevents obesity-induced vascular dysfunction and renal damage in vivo

AIMS/HYPOTHESIS: Obesity causes type 2 diabetes leading to vascular dysfunction and finally renal end-organ damage. Vascular smooth muscle (VSM) EGF receptor (EGFR) modulates vascular wall homeostasis in part via serum response factor (SRF), a major regulator of VSM differentiation and a sensor for...

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Detalles Bibliográficos
Autores principales:	Stern, Christian, Schreier, Barbara, Nolze, Alexander, Rabe, Sindy, Mildenberger, Sigrid, Gekle, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476975/ https://www.ncbi.nlm.nih.gov/pubmed/32548701 http://dx.doi.org/10.1007/s00125-020-05187-4

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