Mitochondrial Mechanisms of LRRK2 G2019S Penetrance

Several mutations in leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson's disease (PD). The most common substitution, G2019S, interferes with LRRK2 kinase activity, which is regulated by autophosphorylation. Yet, the penetrance of this gain-of-function mutation is incomple...

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Detalles Bibliográficos
Autores principales: Delcambre, Sylvie, Ghelfi, Jenny, Ouzren, Nassima, Grandmougin, Léa, Delbrouck, Catherine, Seibler, Philip, Wasner, Kobi, Aasly, Jan O., Klein, Christine, Trinh, Joanne, Pereira, Sandro L., Grünewald, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477385/
https://www.ncbi.nlm.nih.gov/pubmed/32982917
http://dx.doi.org/10.3389/fneur.2020.00881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477385/
https://www.ncbi.nlm.nih.gov/pubmed/32982917
http://dx.doi.org/10.3389/fneur.2020.00881

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