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Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation

Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocai...

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Detalles Bibliográficos
Autores principales: Brami-Cherrier, Karen, Lewis, Robert G., Cervantes, Marlene, Liu, Yu, Tognini, Paola, Baldi, Pierre, Sassone-Corsi, Paolo, Borrelli, Emiliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477550/
https://www.ncbi.nlm.nih.gov/pubmed/32895370
http://dx.doi.org/10.1038/s41467-020-18200-6