The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

Efficient search for DNA damage embedded in vast expanses of the DNA genome presents one of the greatest challenges to DNA repair enzymes. We report here crystal structures of human 8-oxoguanine (oxoG) DNA glycosylase, hOGG1, that interact with the DNA containing the damaged base oxoG and the normal...

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Detalles Bibliográficos
Autores principales: Shigdel, Uddhav K., Ovchinnikov, Victor, Lee, Seung-Joo, Shih, Jenny A., Karplus, Martin, Nam, Kwangho, Verdine, Gregory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477556/
https://www.ncbi.nlm.nih.gov/pubmed/32895378
http://dx.doi.org/10.1038/s41467-020-18290-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477556/
https://www.ncbi.nlm.nih.gov/pubmed/32895378
http://dx.doi.org/10.1038/s41467-020-18290-2

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