Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression

CD4(+) T cell functional inhibition (exhaustion) is a hallmark of malaria and correlates with impaired parasite control and infection chronicity. However, the mechanisms of CD4(+) T cell exhaustion are still poorly understood. In this study, we show that Ag-experienced (Ag-exp) CD4(+) T cell exhaust...

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Detalles Bibliográficos
Autores principales: Villegas-Mendez, Ana, Khandelwal, Garima, McGowan, Lucy M., Dookie, Rebecca S., Haley, Michael J., George, Charlotte, Sims, David, Lord, Graham M., Sinclair, Linda V., Jenner, Richard G., Couper, Kevin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2020
Materias:
Infectious Disease and Host Response
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477746/
https://www.ncbi.nlm.nih.gov/pubmed/32817333
http://dx.doi.org/10.4049/jimmunol.2000450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477746/
https://www.ncbi.nlm.nih.gov/pubmed/32817333
http://dx.doi.org/10.4049/jimmunol.2000450

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