Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia

Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good bioavailabili...

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Detalles Bibliográficos
Autores principales: Li, Xingjian, Payne, Daniel T., Ampolu, Badarinath, Bland, Nicholas, Brown, Jane T., Dutton, Mark J., Fitton, Catherine A., Gulliver, Abigail, Hale, Lee, Hamza, Daniel, Jones, Geraint, Lane, Rebecca, Leach, Andrew G., Male, Louise, Merisor, Elena G., Morton, Michael J., Quy, Alex S., Roberts, Ruth, Scarll, Rosanna, Schulz-Utermoehl, Timothy, Stankovic, Tatjana, Stevenson, Brett, Fossey, John S., Agathanggelou, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478165/
https://www.ncbi.nlm.nih.gov/pubmed/32952998
http://dx.doi.org/10.1039/c9md00297a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478165/
https://www.ncbi.nlm.nih.gov/pubmed/32952998
http://dx.doi.org/10.1039/c9md00297a

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