Cargando…

Design, synthesis, and SAR study of isopropoxy allylbenzene derivatives as 15-lipoxygenase inhibitors

OBJECTIVE(S): Allylbenzenes have been recently developed as inhibitors of lipoxygenases. They decrease peroxidation activity via mimicking 1,4-unsaturated bonds of fatty acids by their allyl portion. We designed and synthesized new derivatives of allyl benzenes (6a-f) with isopropoxy and amide subst...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mousavian, Mina, Alavi, Seyed Jamal, Rahbarian, Raheleh, Rajabian, Majid, M. Orafai, Hossein, Sadeghian, Hamid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mashhad University of Medical Sciences 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478253/ https://www.ncbi.nlm.nih.gov/pubmed/32952943 http://dx.doi.org/10.22038/ijbms.2020.36793.8763

Ejemplares similares

Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors
por: Sadeghian, Hamid, et al.
Publicado: (2018)

O-prenylated 3-carboxycoumarins as a novel class of 15-LOX-1 inhibitors
por: Jabbari, Atena, et al.
Publicado: (2017)

New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors
por: Pooryaghoobi, Nona, et al.
Publicado: (2013)

Covalent Conjugates of Allylbenzenes and Terpenoids as Antibiotics Enhancers with the Function of Prolonged Action
por: Zlotnikov, Igor D., et al.
Publicado: (2023)

Laccase-Catalyzed Oxidation of Allylbenzene Derivatives: Towards a Green Equivalent of Ozonolysis
por: Lecourt, Mathilde, et al.
Publicado: (2021)

Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies
por: Aliabadi, Alireza, et al.
Publicado: (2015)

Isolation, Characterization and Antibacterial Activity of 4-Allylbenzene-1,2-diol from Piper austrosinense
por: Gu, Mengxuan, et al.
Publicado: (2023)

Isopropoxy Benzene Guanidine Kills Staphylococcus aureus Without Detectable Resistance
por: Zhang, Xiufeng, et al.
Publicado: (2021)

Mechanism of Action of Isopropoxy Benzene Guanidine against Multidrug-Resistant Pathogens
por: Li, Jie, et al.
Publicado: (2022)

Isopropoxy Benzene Guanidine Ameliorates Streptococcus suis Infection In Vivo and In Vitro
por: Han, Ning, et al.
Publicado: (2023)

In vitro Antibacterial Activity of Isopropoxy Benzene Guanidine Against Multidrug-Resistant Enterococci
por: Zhang, Xiufeng, et al.
Publicado: (2019)

Pharmacokinetics and pharmacodynamics of isopropoxy benzene guanidine against Clostridium perfringens in an intestinal infection model
por: Lu, Yixing, et al.
Publicado: (2022)

Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin
por: Lu, Yixing, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors
por: Channar, Pervaiz Ali, et al.
Publicado: (2022)

Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment
por: Iranpour, Sonia, et al.
Publicado: (2021)

Avenanthramides as lipoxygenase inhibitors
por: Landberg, Rikard, et al.
Publicado: (2020)

[(Z)-Isopropoxy(4-nitrophenylimino)methanethiolato-κS](tricyclohexylphosphine-κP)gold(I)
por: Ho, Soo Yei, et al.
Publicado: (2009)

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
por: Gheorghe, Karina Roxana, et al.
Publicado: (2009)

Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils
por: Archambault, Anne-Sophie, et al.
Publicado: (2018)

Involvement of 15-lipoxygenase in early stages of atherogenesis
Publicado: (1994)

Regulation and Functions of 15-Lipoxygenases in Human Macrophages
por: Snodgrass, Ryan G., et al.
Publicado: (2019)

Isopropoxy Tetramethyl Dioxaborolane on TiO(2): Reaction Pathway and Formation of a Visible-Light-Sensitive Photocatalyst
por: Lin, Jong-Liang, et al.
Publicado: (2019)

Metabolite Identification of Isopropoxy Benzene Guanidine in Rat Liver Microsomes by Using UHPLC-Q-TOF-MS/MS
por: Lu, Yixing, et al.
Publicado: (2023)

Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies
por: Rai, Ganesha, et al.
Publicado: (2014)

Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity
por: Guo, Hao, et al.
Publicado: (2019)

Pharmacokinetics and Pharmacodynamics of Colistin Combined With Isopropoxy Benzene Guanidine Against mcr-1-Positive Salmonella in an Intestinal Infection Model
por: Kong, Lingli, et al.
Publicado: (2022)

The role of 15 lipoxygenase 1 in asthma comes into focus
por: Boyce, Joshua A.
Publicado: (2022)

Inhibition of tumour growth by lipoxygenase inhibitors.
por: Hussey, H. J., et al.
Publicado: (1996)

A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2
por: Jameson, J. Brian, et al.
Publicado: (2014)

Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease
por: Middleton, Melissa Kristine, et al.
Publicado: (2006)

Tumor-suppressing 15-Lipoxygenase-2: Time for prime time?
por: Guo, Yande, et al.
Publicado: (2014)

A novel role for 12/15-lipoxygenase in regulating autophagy
por: Morgan, Alwena H., et al.
Publicado: (2014)

15-Lipoxygenase-1 Is Involved in the Effects of Atorvastatin on Endothelial Dysfunction
por: Zhang, Peng, et al.
Publicado: (2016)

The green microalga Lobosphaera incisa harbours an arachidonate 15S‐lipoxygenase
por: Djian, B., et al.
Publicado: (2018)

12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes
por: Cakir-Aktas, Canan, et al.
Publicado: (2023)

Bioactive Peptides and Protein Hydrolysates as Lipoxygenase Inhibitors
por: Wong, Fai-Chu, et al.
Publicado: (2023)

Fast and Green Microwave-Assisted Conversion of Essential Oil Allylbenzenes into the Corresponding Aldehydes via Alkene Isomerization and Subsequent Potassium Permanganate Promoted Oxidative Alkene Group Cleavage
por: Luu, Thi Xuan Thi, et al.
Publicado: (2009)

Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents
por: Venugopala, Katharigatta N, et al.
Publicado: (2015)

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase
por: Meirer, Karin, et al.
Publicado: (2016)

Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure
por: Kayama, Yosuke, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_dljahtu0lqtc4uthrqi50bcvos