Repolarization instability and arrhythmia by I(Kr) block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D monolayers

AIMS: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have proven valuable for studies in drug discovery and safety, although limitations regarding their structural and electrophysiological characteristics persist. In this study, we investigated the electrophysiological proper...

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Detalles Bibliográficos
Autores principales: Altrocchi, Cristina, de Korte, Tessa, Bernardi, Joyce, Spätjens, Roel L H M G, Braam, Stefan R, Heijman, Jordi, Zaza, Antonio, Volders, Paul G A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478319/
https://www.ncbi.nlm.nih.gov/pubmed/32770183
http://dx.doi.org/10.1093/europace/euaa111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478319/
https://www.ncbi.nlm.nih.gov/pubmed/32770183
http://dx.doi.org/10.1093/europace/euaa111

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