Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion

The monoallelic expression of antigen receptor (AgR) genes, called allelic exclusion, is fundamental for highly specific immune responses to pathogens. This cardinal feature of adaptive immunity is achieved by the assembly of a functional AgR gene on one allele, with subsequent feedback inhibition o...

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Detalles Bibliográficos
Autores principales: Wu, Glendon S., Yang-Iott, Katherine S., Klink, Morgann A., Hayer, Katharina E., Lee, Kyutae D., Bassing, Craig H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478721/
https://www.ncbi.nlm.nih.gov/pubmed/32526772
http://dx.doi.org/10.1084/jem.20200412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478721/
https://www.ncbi.nlm.nih.gov/pubmed/32526772
http://dx.doi.org/10.1084/jem.20200412

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