Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer’s disease (AD) risk. In mouse models of amyloid β (Aβ) accumulation, defective TREM2 function affects microglial response to Aβ plaques, exacerbating tissue damage, w...

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Detalles Bibliográficos
Autores principales: Wang, Shoutang, Mustafa, Meer, Yuede, Carla M., Salazar, Santiago Viveros, Kong, Philip, Long, Hua, Ward, Michael, Siddiqui, Omer, Paul, Robert, Gilfillan, Susan, Ibrahim, Adiljan, Rhinn, Hervé, Tassi, Ilaria, Rosenthal, Arnon, Schwabe, Tina, Colonna, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478730/
https://www.ncbi.nlm.nih.gov/pubmed/32579671
http://dx.doi.org/10.1084/jem.20200785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478730/
https://www.ncbi.nlm.nih.gov/pubmed/32579671
http://dx.doi.org/10.1084/jem.20200785

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