Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons

TRIP8b (tetratricopeptide repeat–containing Rab8b-interacting protein) is the neuronal regulatory subunit of HCN channels, a family of voltage-dependent cation channels also modulated by direct cAMP binding. TRIP8b interacts with the C-terminal region of HCN channels and controls both channel traffi...

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Detalles Bibliográficos
Autores principales: Porro, Alessandro, Binda, Anna, Pisoni, Matteo, Donadoni, Chiara, Rivolta, Ilaria, Saponaro, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478871/
https://www.ncbi.nlm.nih.gov/pubmed/32633755
http://dx.doi.org/10.1085/jgp.202012596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478871/
https://www.ncbi.nlm.nih.gov/pubmed/32633755
http://dx.doi.org/10.1085/jgp.202012596

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