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Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor

The α7 nicotinic acetylcholine receptor (nAChR) is among the most abundant types of nAChR in the brain, yet the ability of nerve-released ACh to activate α7 remains enigmatic. In particular, a major population of α7 resides in extra-synaptic regions where the ACh concentration is reduced, owing to d...

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Detalles Bibliográficos
Autores principales: Natarajan, Kathiresan, Mukhtasimova, Nuriya, Corradi, Jeremías, Lasala, Matías, Bouzat, Cecilia, Sine, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478872/
https://www.ncbi.nlm.nih.gov/pubmed/32702089
http://dx.doi.org/10.1085/jgp.202012606