Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice

PURPOSE: TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) currently under clinical development for schizophrenia. In this study, a mechanistic multilayer quantitative model that parsimoniously connects pharmacokinetics (PK), target occupancy (TO) and D-serine concent...

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Detalles Bibliográficos
Autores principales: Yoneyama, Tomoki, Sato, Sho, Sykes, Andy, Fradley, Rosa, Stafford, Stuart, Bechar, Shyam, Howley, Eimear, Patel, Toshal, Tagawa, Yoshihiko, Moriwaki, Toshiya, Asahi, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478952/
https://www.ncbi.nlm.nih.gov/pubmed/32901384
http://dx.doi.org/10.1007/s11095-020-02893-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478952/
https://www.ncbi.nlm.nih.gov/pubmed/32901384
http://dx.doi.org/10.1007/s11095-020-02893-x

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