Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin

The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. Here, we describe a mouse model in which Z-disc-anchored TTN is depleted in adult skeletal muscles. Inactivation of TTN causes sarcomere disassembly and...

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Detalles Bibliográficos
Autores principales: Swist, Sandra, Unger, Andreas, Li, Yong, Vöge, Anja, von Frieling-Salewsky, Marion, Skärlén, Åsa, Cacciani, Nicola, Braun, Thomas, Larsson, Lars, Linke, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478974/
https://www.ncbi.nlm.nih.gov/pubmed/32900999
http://dx.doi.org/10.1038/s41467-020-18131-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478974/
https://www.ncbi.nlm.nih.gov/pubmed/32900999
http://dx.doi.org/10.1038/s41467-020-18131-2

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