Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

Macroautophagy initiates by formation of isolation membranes, but the source of phospholipids for the membrane biogenesis remains elusive. Here, we show that autophagic membranes incorporate newly synthesized phosphatidylcholine, and that CTP:phosphocholine cytidylyltransferase β3 (CCTβ3), an isofor...

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Detalles Bibliográficos
Autores principales: Ogasawara, Yuta, Cheng, Jinglei, Tatematsu, Tsuyako, Uchida, Misaki, Murase, Omi, Yoshikawa, Shogo, Ohsaki, Yuki, Fujimoto, Toyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479109/
https://www.ncbi.nlm.nih.gov/pubmed/32900992
http://dx.doi.org/10.1038/s41467-020-18153-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479109/
https://www.ncbi.nlm.nih.gov/pubmed/32900992
http://dx.doi.org/10.1038/s41467-020-18153-w

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