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IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon
The physiological stresses that diminish tissue stem-cell characteristics remain largely unknown. We previously reported that type I interferon (IFN), which is essential for host antiviral responses, is a physiological stressor for hematopoietic stem cells (HSCs) and small intestinal stem cells (ISC...
Autores principales: | Minamide, Kana, Sato, Taku, Nakanishi, Yusuke, Ohno, Hiroshi, Kato, Tamotsu, Asano, Jumpei, Ohteki, Toshiaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479133/ https://www.ncbi.nlm.nih.gov/pubmed/32901054 http://dx.doi.org/10.1038/s41598-020-71633-3 |
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