L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells

We sought to determine a mechanism by which L-arginine increases glucose-stimulated insulin secretion (GSIS) in β-cells by finding a protein with affinity to L-arginine using arginine-immobilized magnetic nanobeads technology. Glucokinase (GCK), the key regulator of GSIS and a disease-causing gene o...

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Detalles Bibliográficos
Autores principales: Cho, Jaeyong, Horikawa, Yukio, Enya, Mayumi, Takeda, Jun, Imai, Yoichi, Imai, Yumi, Handa, Hiroshi, Imai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479149/
https://www.ncbi.nlm.nih.gov/pubmed/32901087
http://dx.doi.org/10.1038/s42003-020-01226-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479149/
https://www.ncbi.nlm.nih.gov/pubmed/32901087
http://dx.doi.org/10.1038/s42003-020-01226-3

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