KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface

RAS proteins function as highly regulated molecular switches that control cellular growth. In addition to regulatory proteins, RAS undergoes a number of posttranslational modifications (PTMs) that regulate its activity. Lysine 104, a hot spot for multiple PTMs, is a highly conserved residue that for...

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Detalles Bibliográficos
Autores principales: Yin, Guowei, Zhang, Jerry, Nair, Vinay, Truong, Vinh, Chaia, Angelo, Petela, Johnny, Harrison, Joseph, Gorfe, Alemayehu A., Campbell, Sharon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479270/
https://www.ncbi.nlm.nih.gov/pubmed/32882514
http://dx.doi.org/10.1016/j.isci.2020.101448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479270/
https://www.ncbi.nlm.nih.gov/pubmed/32882514
http://dx.doi.org/10.1016/j.isci.2020.101448

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