Lactate activation of α-cell K(ATP) channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca(2+) entry

OBJECTIVE: Elevations in pancreatic α-cell intracellular Ca(2+) ([Ca(2+)](i)) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca(2+) handling is unknown. Lactate enters cells through monocarboxylate transporters (MCTs) and is also pr...

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Detalles Bibliográficos
Autores principales: Zaborska, Karolina E., Dadi, Prasanna K., Dickerson, Matthew T., Nakhe, Arya Y., Thorson, Ariel S., Schaub, Charles M., Graff, Sarah M., Stanley, Jade E., Kondapavuluru, Roy S., Denton, Jerod S., Jacobson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479281/
https://www.ncbi.nlm.nih.gov/pubmed/32736089
http://dx.doi.org/10.1016/j.molmet.2020.101056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479281/
https://www.ncbi.nlm.nih.gov/pubmed/32736089
http://dx.doi.org/10.1016/j.molmet.2020.101056

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