The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation

In de novo purine biosynthesis (DNPS), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (EC 2.1.2.3)/inosine monophosphate cyclohydrolase (EC 3.5.4.10) (ATIC) catalyzes the last two reactions of the pathway: conversion of 5-aminoimidazole-4-carboxamide ribonucleotide [aka Z-nucleotide...

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Detalles Bibliográficos
Autores principales: Mazzarino, Randall C., Baresova, Veronika, Zikánová, Marie, Duval, Nathan, Wilkinson, Terry G., Patterson, David, Vacano, Guido N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479443/
https://www.ncbi.nlm.nih.gov/pubmed/32939338
http://dx.doi.org/10.1016/j.ymgmr.2020.100642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479443/
https://www.ncbi.nlm.nih.gov/pubmed/32939338
http://dx.doi.org/10.1016/j.ymgmr.2020.100642

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