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IL-36 receptor antagonist deficiency resulted in delayed wound healing due to excessive recruitment of immune cells

Loss-of-function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin-36 receptor antagonist (IL-36Ra), have been implicated in the pathogenesis of various skin disorders. Previous findings showed that IL-36γ promoted wound healing in mice; however, the pathogenic role...

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Detalles Bibliográficos
Autores principales: Saito, Kenta, Iwata, Yohei, Fukushima, Hidehiko, Watanabe, Soichiro, Tanaka, Yoshihito, Hasegawa, Yurie, Akiyama, Masashi, Sugiura, Kazumitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479622/
https://www.ncbi.nlm.nih.gov/pubmed/32901055
http://dx.doi.org/10.1038/s41598-020-71256-8