Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism

Neurexins are presynaptic adhesion molecules that organize synapses by binding to diverse trans-synaptic ligands, but how neurexins are regulated is incompletely understood. Here we identify FAM19A/TAFA proteins, “orphan" cytokines, as neurexin regulators that interact with all neurexins, excep...

Descripción completa

Detalles Bibliográficos
Autores principales: Khalaj, Anna J., Sterky, Fredrik H., Sclip, Alessandra, Schwenk, Jochen, Brunger, Axel T., Fakler, Bernd, Südhof, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480106/
https://www.ncbi.nlm.nih.gov/pubmed/32706374
http://dx.doi.org/10.1083/jcb.202004164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480106/
https://www.ncbi.nlm.nih.gov/pubmed/32706374
http://dx.doi.org/10.1083/jcb.202004164

Ejemplares similares