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Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism
Neurexins are presynaptic adhesion molecules that organize synapses by binding to diverse trans-synaptic ligands, but how neurexins are regulated is incompletely understood. Here we identify FAM19A/TAFA proteins, “orphan" cytokines, as neurexin regulators that interact with all neurexins, excep...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480106/ https://www.ncbi.nlm.nih.gov/pubmed/32706374 http://dx.doi.org/10.1083/jcb.202004164 |