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Epigenetic modulation of the MAPK pathway prevents isoflurane-induced neuronal apoptosis and cognitive decline in aged rats
Isoflurane is a broadly used inhalation anesthetic that causes cognitive impairment in rodent models as well as humans. Although previous studies suggested an association between isoflurane exposure and neuro-inflammation, apoptosis and mitochondrial dysfunction, the pathogenesis of isoflurane-induc...
Autores principales: | Huang, Lei, Fang, Hai-Bin, Cheng, Hui-Hui, Mei, Sheng-Lan, Cheng, Yun-Ping, Lv, Yao, Meng, Qing-Tao, Xia, Zhong-Yuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480129/ https://www.ncbi.nlm.nih.gov/pubmed/32952626 http://dx.doi.org/10.3892/etm.2020.9162 |
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