Cargando…

Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells

The macrocyclization of recombinant polypeptides by means of genetically encodable non-canonical amino acids has recently provided an attractive strategy for the screening and discovery of macrocyclic peptide inhibitors of protein–protein interactions. Here, we report the development of an expanded...

Descripción completa

Detalles Bibliográficos
Autores principales: Iannuzzelli, Jacob A., Fasan, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480269/
https://www.ncbi.nlm.nih.gov/pubmed/32953014
http://dx.doi.org/10.1039/d0sc01699c