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Cu(A)-based chimeric T1 copper sites allow for independent modulation of reorganization energy and reduction potential

Attaining rational modulation of thermodynamic and kinetic redox parameters of metalloproteins is a key milestone towards the (re)design of proteins with new or improved redox functions. Here we report that implantation of ligand loops from natural T1 proteins into the scaffold of a Cu(A) protein le...

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Detalles Bibliográficos
Autores principales: Szuster, Jonathan, Zitare, Ulises A., Castro, María A., Leguto, Alcides J., Morgada, Marcos N., Vila, Alejandro J., Murgida, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480511/
https://www.ncbi.nlm.nih.gov/pubmed/32953013
http://dx.doi.org/10.1039/d0sc01620a