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Cu(A)-based chimeric T1 copper sites allow for independent modulation of reorganization energy and reduction potential
Attaining rational modulation of thermodynamic and kinetic redox parameters of metalloproteins is a key milestone towards the (re)design of proteins with new or improved redox functions. Here we report that implantation of ligand loops from natural T1 proteins into the scaffold of a Cu(A) protein le...
Autores principales: | Szuster, Jonathan, Zitare, Ulises A., Castro, María A., Leguto, Alcides J., Morgada, Marcos N., Vila, Alejandro J., Murgida, Daniel H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480511/ https://www.ncbi.nlm.nih.gov/pubmed/32953013 http://dx.doi.org/10.1039/d0sc01620a |
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