Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

Systemic hypertension increases cardiac workload causing cardiomyocyte hypertrophy and increased cardiac fibrosis. An underlying feature is increased production of reactive oxygen species. Redox-sensitive ASK1 (apoptosis signal-regulating kinase 1) activates stress-regulated protein kinases (p38-MAP...

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Detalles Bibliográficos
Autores principales: Meijles, Daniel N., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T.E., Haines, Zoe H.R., Fuller, Stephen J., O’Gara, Peter, Sheppard, Mary N., Harding, Sian E., Sugden, Peter H., Clerk, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480944/
https://www.ncbi.nlm.nih.gov/pubmed/32903101
http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480944/
https://www.ncbi.nlm.nih.gov/pubmed/32903101
http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14556

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