Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis

Streptovaricin C is a naphthalenic ansamycin antibiotic structurally similar to rifamycins with potential anti-MRSA bioactivities. However, the formation mechanism of the most fascinating and bioactivity-related methylenedioxy bridge (MDB) moiety in streptovaricins is unclear. Based on genetic and b...

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Detalles Bibliográficos
Autores principales: Sun, Guo, Hu, Chaoqun, Mei, Qing, Luo, Minghe, Chen, Xu, Li, Zhengyuan, Liu, Yuanzhen, Deng, Zixin, Zhang, Zhengyu, Sun, Yuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481197/
https://www.ncbi.nlm.nih.gov/pubmed/32908132
http://dx.doi.org/10.1038/s41467-020-18336-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481197/
https://www.ncbi.nlm.nih.gov/pubmed/32908132
http://dx.doi.org/10.1038/s41467-020-18336-5

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