Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion

Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung tumors resistant to PD-1/PD-L1 blockade. Additionally, elevated collagen correlates with decreased total CD8(+) T cells and increased...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, David H., Rodriguez, Bertha Leticia, Diao, Lixia, Chen, Limo, Wang, Jing, Byers, Lauren A., Wei, Ying, Chapman, Harold A., Yamauchi, Mitsuo, Behrens, Carmen, Raso, Gabriela, Soto, Luisa Maren Solis, Cuentes, Edwin Roger Parra, Wistuba, Ignacio I., Kurie, Jonathan M., Gibbons, Don L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481212/
https://www.ncbi.nlm.nih.gov/pubmed/32908154
http://dx.doi.org/10.1038/s41467-020-18298-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481212/
https://www.ncbi.nlm.nih.gov/pubmed/32908154
http://dx.doi.org/10.1038/s41467-020-18298-8

Ejemplares similares