Transgenerational inheritance of impaired larval T cell development in zebrafish

Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Aberrant patterns of DNA methylation in gametes may set the stage for transmission into future generations. Here, we describe a viable hypomorphic allele of dnmt1 in zebrafish that causes widespread demeth...

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Detalles Bibliográficos
Autores principales: Iwanami, Norimasa, Lawir, Divine-Fondzenyuy, Sikora, Katarzyna, O´Meara, Connor, Takeshita, Kohei, Schorpp, Michael, Boehm, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481223/
https://www.ncbi.nlm.nih.gov/pubmed/32908148
http://dx.doi.org/10.1038/s41467-020-18289-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481223/
https://www.ncbi.nlm.nih.gov/pubmed/32908148
http://dx.doi.org/10.1038/s41467-020-18289-9

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