Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma

NAMPT mediates the rate-limiting step of the NAD salvage pathway, which maintains cellular bioenergetics and provides a necessary substrate for functions essential to rapidly proliferating cancer cells. In this study, we evaluated the efficacy and mechanisms of action of OT-82, a novel, high-potency...

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Detalles Bibliográficos
Autores principales: Gibson, Anna E., Yeung, Choh, Issaq, Sameer H., Collins, Victor J., Gouzoulis, Michael, Zhang, Yiping, Ji, Jiuping, Mendoza, Arnulfo, Heske, Christine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481307/
https://www.ncbi.nlm.nih.gov/pubmed/32908120
http://dx.doi.org/10.1038/s41389-020-00264-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481307/
https://www.ncbi.nlm.nih.gov/pubmed/32908120
http://dx.doi.org/10.1038/s41389-020-00264-0

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