Cargando…

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma

NAMPT mediates the rate-limiting step of the NAD salvage pathway, which maintains cellular bioenergetics and provides a necessary substrate for functions essential to rapidly proliferating cancer cells. In this study, we evaluated the efficacy and mechanisms of action of OT-82, a novel, high-potency...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gibson, Anna E., Yeung, Choh, Issaq, Sameer H., Collins, Victor J., Gouzoulis, Michael, Zhang, Yiping, Ji, Jiuping, Mendoza, Arnulfo, Heske, Christine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481307/ https://www.ncbi.nlm.nih.gov/pubmed/32908120 http://dx.doi.org/10.1038/s41389-020-00264-0

Ejemplares similares

Association of Nicotinamide Phosphoribosyltransferase (NAMPT) Gene Polymorphisms and of Serum NAMPT Levels with Dilated Cardiomyopathy in a Chinese Population
por: Dou, Qingyu, et al.
Publicado: (2015)

Metabolomics Analysis of Metabolic Effects of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibition on Human Cancer Cells
por: Tolstikov, Vladimir, et al.
Publicado: (2014)

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy
por: LoCoco, Peter M, et al.
Publicado: (2017)

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents
por: Conforti, Irene, et al.
Publicado: (2023)

Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway
por: Feng, Duo, et al.
Publicado: (2020)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer
por: Travelli, Cristina, et al.
Publicado: (2023)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma
por: Audrito, Valentina, et al.
Publicado: (2018)

Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target
por: Sun, Belinda L, et al.
Publicado: (2020)

Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
por: Aprile, Silvio, et al.
Publicado: (2019)

Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects
por: Saddi-Rosa, Pedro, et al.
Publicado: (2013)

The Role of PDGFR-β Activation in Acquired Resistance to IGF-1R Blockade in Preclinical Models of Rhabdomyosarcoma()
por: Heske, Christine M., et al.
Publicado: (2016)

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes
por: Yammani, Raghunatha R, et al.
Publicado: (2012)

Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy
por: Deng, Yang, et al.
Publicado: (2022)

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma()
por: Wan, Xiaolin, et al.
Publicado: (2015)

Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans
por: Friebe, D., et al.
Publicado: (2011)

Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects
por: Goktas, Zeynep, et al.
Publicado: (2013)

Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves’ opthalmopathy
por: Sawicka-Gutaj, Nadia, et al.
Publicado: (2016)

The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5)
por: Torretta, Simone, et al.
Publicado: (2020)

Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma
por: Hara, Nobumasa, et al.
Publicado: (2011)

Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine
por: Grolla, Ambra A, et al.
Publicado: (2016)

Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase
por: Zhang, Li Q, et al.
Publicado: (2017)

Correction: Feng et al. Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway. Int. J. Mol. Sci. 2020, 21, 4655
por: Feng, Duo, et al.
Publicado: (2021)

Nicotinamide Phosphoribosyltransferase May Be Involved in Age-Related Brain Diseases
por: Liu, Li-Ying, et al.
Publicado: (2012)

Prognostic value of serum nicotinamide phosphoribosyltransferase in patients with bladder cancer
por: Zhang, Kui, et al.
Publicado: (2014)

Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors
por: Tanuma, Sei-ichi, et al.
Publicado: (2020)

Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process
por: Khaidizar, Fiqri D., et al.
Publicado: (2021)

Nicotinamide phosphoribosyltransferase as a biomarker for the diagnosis of infectious pleural effusions
por: Huang, Jing, et al.
Publicado: (2021)

Nicotinamide phosphoribosyltransferase regulates the cell differentiation and mineralization in cultured odontoblasts
por: Kang, Kyeong-Rok, et al.
Publicado: (2022)

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies
por: Biniecka, Paulina, et al.
Publicado: (2023)

Extracellular nicotinamide phosphoribosyltransferase: role in disease pathophysiology and as a biomarker
por: Semerena, Elise, et al.
Publicado: (2023)

Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy
por: Heske, Christine M.
Publicado: (2020)

Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase
por: Xu, Tian-Ying, et al.
Publicado: (2015)

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates
por: Karpov, Alexei S., et al.
Publicado: (2018)

Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors
por: Sadrerafi, Keivan, et al.
Publicado: (2018)

Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro
por: Funk, RS, et al.
Publicado: (2016)

Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase
por: Ling, Min, et al.
Publicado: (2017)

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype
por: Kuehnemann, Chisaka, et al.
Publicado: (2022)

Changes of Nicotinamide Phosphoribosyltransferase Expressions in Thyroid Glands of Patients with Different Thyroid Pathologies
por: Sawicka-Gutaj, Nadia, et al.
Publicado: (2018)

Nicotinamide phosphoribosyltransferase-related signaling pathway in early Alzheimer's disease mouse models
por: Xing, Sanli, et al.
Publicado: (2019)

SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase
por: Higgins, Cassandra B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u9he4r8tkqcoednikgd3sps5at