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Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease
Alzheimer’s disease (AD) is pathologically defined by extracellular accumulation of amyloid-β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of hyperphosphorylated Tau proteins accumulating inside neurons known as neurofibrillary tangles (NFTs) and neuronal loss....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481386/ https://www.ncbi.nlm.nih.gov/pubmed/33061903 http://dx.doi.org/10.3389/fnagi.2020.00265 |