Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

Alzheimer’s disease (AD) is pathologically defined by extracellular accumulation of amyloid-β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of hyperphosphorylated Tau proteins accumulating inside neurons known as neurofibrillary tangles (NFTs) and neuronal loss....

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Detalles Bibliográficos
Autores principales: d‘Errico, Paolo, Meyer-Luehmann, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481386/
https://www.ncbi.nlm.nih.gov/pubmed/33061903
http://dx.doi.org/10.3389/fnagi.2020.00265

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