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In Vivo Structural and Functional Abnormalities of the Striatums Is Related to Decreased Astrocytic BDNF in Itpr2(−/−) Mice Exhibiting Depressive-Like Behavior

BACKGROUND: Previous researches indicate that Itpr2(−/−) mice (inositol 1,4,5-trisphosphate receptor type 2 knockout mice) show depressive-like symptoms; however, little is known regarding the in vivo neurobiological effect of Itpr2 as well as the specific pattern of brain abnormalities in Itpr2(−/−...

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Detalles Bibliográficos
Autores principales: Zeng, Shanmei, Liu, Kai, Zhang, Jingyu, Chen, Chunhui, Xu, Yihua, Wu, Yulan, Deng, Yanjia, Sun, Xuegang, Wen, Ge, Jing, Linlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481938/
https://www.ncbi.nlm.nih.gov/pubmed/32952549
http://dx.doi.org/10.1155/2020/8830670