Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair

p53-binding protein 1 (53BP1) exerts distinct impacts in different situations involving DNA double-strand break (DSB) rejoining. Here we focus on how 53BP1 impacts upon the repair of ionising radiation-induced DSBs (IR-DSBs) and how it interfaces with Ku, the DNA end-binding component of canonical n...

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Detalles Bibliográficos
Autores principales: Shibata, Atsushi, Jeggo, Penny A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482155/
https://www.ncbi.nlm.nih.gov/pubmed/32779701
http://dx.doi.org/10.1093/jrr/rraa053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482155/
https://www.ncbi.nlm.nih.gov/pubmed/32779701
http://dx.doi.org/10.1093/jrr/rraa053

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