CD25-targeted antibody–drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity

BACKGROUND: Regulatory T cells (T(regs)) contribute to an immunosuppressive tumor microenvironment. They play an important role in the establishment and progression of tumors with high T(regs) infiltration and present a major obstacle to tumor eradication by immunotherapies. Numerous strategies have...

Descripción completa

Detalles Bibliográficos
Autores principales: Zammarchi, Francesca, Havenith, Karin, Bertelli, Francois, Vijayakrishnan, Balakumar, Chivers, Simon, van Berkel, Patrick H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482493/
https://www.ncbi.nlm.nih.gov/pubmed/32912922
http://dx.doi.org/10.1136/jitc-2020-000860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482493/
https://www.ncbi.nlm.nih.gov/pubmed/32912922
http://dx.doi.org/10.1136/jitc-2020-000860

Ejemplares similares