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CD25-targeted antibody–drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity

BACKGROUND: Regulatory T cells (T(regs)) contribute to an immunosuppressive tumor microenvironment. They play an important role in the establishment and progression of tumors with high T(regs) infiltration and present a major obstacle to tumor eradication by immunotherapies. Numerous strategies have...

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Detalles Bibliográficos
Autores principales:	Zammarchi, Francesca, Havenith, Karin, Bertelli, Francois, Vijayakrishnan, Balakumar, Chivers, Simon, van Berkel, Patrick H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482493/ https://www.ncbi.nlm.nih.gov/pubmed/32912922 http://dx.doi.org/10.1136/jitc-2020-000860

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