Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model

Mutations in human metabolic genes can lead to rare diseases known as inborn errors of human metabolism. For instance, patients with loss-of-function mutations in either subunit of propionyl-CoA carboxylase suffer from propionic acidemia because they cannot catabolize propionate, leading to its harm...

Descripción completa

Detalles Bibliográficos
Autores principales: Na, Huimin, Zdraljevic, Stefan, Tanny, Robyn E., Walhout, Albertha J. M., Andersen, Erik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482840/
https://www.ncbi.nlm.nih.gov/pubmed/32857789
http://dx.doi.org/10.1371/journal.pgen.1008984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482840/
https://www.ncbi.nlm.nih.gov/pubmed/32857789
http://dx.doi.org/10.1371/journal.pgen.1008984

Ejemplares similares