G10 is a direct activator of human STING

The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and activate the adaptor STING, leading to downstream secretion of Type I interferons and other pro-inflammatory NFκB pathway cytokines. In the m...

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Detalles Bibliográficos
Autores principales: Banerjee, Monali, Middya, Sandip, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Pryde, David C., Yadav, Dharmendra B., Surya, Arjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482845/
https://www.ncbi.nlm.nih.gov/pubmed/32911484
http://dx.doi.org/10.1371/journal.pone.0237743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482845/
https://www.ncbi.nlm.nih.gov/pubmed/32911484
http://dx.doi.org/10.1371/journal.pone.0237743

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