Obeticholic acid reduces biliary and hepatic matrix metalloproteinases activity in rat hepatic ischemia/reperfusion injury

BACKGROUND: We have previously shown that obeticholic acid (OCA) upregulates the biliary excretion of asymmetric dimethylarginine (ADMA), an inhibitor of iNOS regulating the activity of matrix metalloproteinases (MMPs). Here, the effects of OCA on MMP-2 and MMP-9 activity in liver, bile and serum we...

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Detalles Bibliográficos
Autores principales: Ferrigno, Andrea, Palladini, Giuseppina, Di Pasqua, Laura Giuseppina, Berardo, Clarissa, Richelmi, Plinio, Cadamuro, Massimiliano, Fabris, Luca, Perlini, Stefano, Adorini, Luciano, Vairetti, Mariapia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482919/
https://www.ncbi.nlm.nih.gov/pubmed/32911524
http://dx.doi.org/10.1371/journal.pone.0238543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482919/
https://www.ncbi.nlm.nih.gov/pubmed/32911524
http://dx.doi.org/10.1371/journal.pone.0238543

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