Reversal of Synaptic and Behavioral Deficits in a 16p11.2 Duplication Mouse Model via Restoration of the GABA Synapse Regulator Npas4

The human 16p11.2 gene locus is a hot-spot for copy number variations which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability (ID) and schizophrenia (SZ). Despite the debilitating na...

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Detalles Bibliográficos
Autores principales: Rein, Benjamin, Tan, Tao, Yang, Fengwei, Wang, Wei, Williams, Jamal, Zhang, Freddy, Mills, Alea, Yan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483162/
https://www.ncbi.nlm.nih.gov/pubmed/32099100
http://dx.doi.org/10.1038/s41380-020-0693-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483162/
https://www.ncbi.nlm.nih.gov/pubmed/32099100
http://dx.doi.org/10.1038/s41380-020-0693-9

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