Cargando…

Reversal of Synaptic and Behavioral Deficits in a 16p11.2 Duplication Mouse Model via Restoration of the GABA Synapse Regulator Npas4

The human 16p11.2 gene locus is a hot-spot for copy number variations which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability (ID) and schizophrenia (SZ). Despite the debilitating na...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rein, Benjamin, Tan, Tao, Yang, Fengwei, Wang, Wei, Williams, Jamal, Zhang, Freddy, Mills, Alea, Yan, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483162/ https://www.ncbi.nlm.nih.gov/pubmed/32099100 http://dx.doi.org/10.1038/s41380-020-0693-9

Ejemplares similares

Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion
por: Wang, Wei, et al.
Publicado: (2022)

Sensory processing in 16p11.2 deletion and 16p11.2 duplication
por: Smith, Harriet, et al.
Publicado: (2022)

Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release
por: Opsomer, Rémi, et al.
Publicado: (2020)

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family
por: Sun, Xiangnan, et al.
Publicado: (2022)

Psychiatric disorders in children with 16p11.2 deletion and duplication
por: Niarchou, Maria, et al.
Publicado: (2019)

Correction: Psychiatric disorders in children with 16p11.2 deletion and duplication
por: Niarchou, Maria, et al.
Publicado: (2019)

NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus
por: Hartzell, Andrea L, et al.
Publicado: (2018)

Transposition of the great arteries - a phenotype associated with 16p11.2 duplications?
por: Karunanithi, Zarmiga, et al.
Publicado: (2017)

Neuro-Behavioral Phenotype in 16p11.2 Duplication: A Case Series
por: Posar, Annio, et al.
Publicado: (2020)

Paroxysmal Kinesigenic Dyskinesia in Twins With Chromosome 16p11.2 Duplication Syndrome
por: Ueda, Keisuke, et al.
Publicado: (2021)

A NPAS4–NuA4 complex couples synaptic activity to DNA repair
por: Pollina, Elizabeth A., et al.
Publicado: (2023)

Contribution of mGluR5 to hippocampal pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion
por: Tian, Di, et al.
Publicado: (2015)

Excitatory Dysfunction Drives Network and Calcium Handling Deficits in 16p11.2 Duplication Schizophrenia Induced Pluripotent Stem Cell–Derived Neurons
por: Parnell, Euan, et al.
Publicado: (2023)

Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication
por: Hasegawa, Yuto, et al.
Publicado: (2023)

Isolation and Characterization of Chicken NPAS3
por: Shin, Jiheon, et al.
Publicado: (2010)

Molecular characterisation of rare loss-of-function NPAS3 and NPAS4 variants identified in individuals with neurodevelopmental disorders
por: Rossi, Joseph J., et al.
Publicado: (2021)

A Rare Duplication on Chromosome 16p11.2 Is Identified in Patients with Psychosis in Alzheimer's Disease
por: Zheng, Xiaojing, et al.
Publicado: (2014)

Modulation of mu attenuation to social stimuli in children and adults with 16p11.2 deletions and duplications
por: Hudac, Caitlin M., et al.
Publicado: (2015)

Deletion and duplication of 16p11.2 are associated with opposing effects on visual evoked potential amplitude
por: LeBlanc, Jocelyn J., et al.
Publicado: (2016)

Clinical Characteristics of Seizures and Epilepsy in Individuals With Recurrent Deletions and Duplications in the 16p11.2 Region
por: Moufawad El Achkar, Christelle, et al.
Publicado: (2022)

Blocking Astrocytic GABA Restores Synaptic Plasticity in Prefrontal Cortex of Rat Model of Depression
por: Srivastava, Ipsit, et al.
Publicado: (2020)

The synaptic scaffold protein MPP2 interacts with GABA(A) receptors at the periphery of the postsynaptic density of glutamatergic synapses
por: Schmerl, Bettina, et al.
Publicado: (2022)

γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors
por: Dixon, Christine L., et al.
Publicado: (2017)

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning
por: Sidlauskaite, Eva, et al.
Publicado: (2018)

NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses
por: Hughes, Brandon W, et al.
Publicado: (2023)

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes
por: Arbogast, Thomas, et al.
Publicado: (2016)

Downregulation of Npas4 in parvalbumin interneurons and cognitive deficits after neonatal NMDA receptor blockade: relevance for schizophrenia
por: Shepard, Ryan, et al.
Publicado: (2019)

Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications
por: Wegiel, Jerzy, et al.
Publicado: (2015)

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder
por: Brunner, Daniela, et al.
Publicado: (2015)

Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease
por: Cao, Qing, et al.
Publicado: (2020)

R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice
por: Stoppel, Laura J, et al.
Publicado: (2018)

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity
por: Savtchenko, Leonid, et al.
Publicado: (2015)

Glial response to hypoxia in mutants of NPAS1/3 homolog Trachealess through Wg signaling to modulate synaptic bouton organization
por: Chen, Pei-Yi, et al.
Publicado: (2019)

Case Report: Novel Copy Number Variant 16p11.2 Duplication Associated With Prune Belly Syndrome
por: Talluri, Sriharsha, et al.
Publicado: (2021)

Dysregulation of Npas4 and Inhba expression and an altered excitation–inhibition balance are associated with cognitive deficits in DBA/2 mice
por: Oberländer, Kristin, et al.
Publicado: (2022)

NPAS3 variants in schizophrenia: a neuroimaging study
por: Bernier, Denise, et al.
Publicado: (2014)

The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia
por: Choy, Fong Chan, et al.
Publicado: (2015)

Structural insights and characterization of human Npas4 protein
por: Fahim, Ammad, et al.
Publicado: (2018)

Molecular analysis of NPAS3 functional domains and variants
por: Luoma, Leiah M., et al.
Publicado: (2018)

NPAS4L is involved in avian hemangioblast specification
por: Weng, Wei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k1fa12s05u12c1vcdf63fsk1h1