Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation

The SHANK3 gene encodes a postsynaptic scaffold protein in excitatory synapses, and its disruption is implicated in neurodevelopmental disorders such as Phelan-McDermid syndrome, autism spectrum disorder, and schizophrenia. Most studies of SHANK3 in the neocortex and hippocampus have focused on dist...

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Detalles Bibliográficos
Autores principales: Ali, Farhan, Shao, Ling-Xiao, Gerhard, Danielle M., Sweasy, Katherine, Pothula, Santosh, Pittenger, Christopher, Duman, Ronald S., Kwan, Alex C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483244/
https://www.ncbi.nlm.nih.gov/pubmed/32161363
http://dx.doi.org/10.1038/s41380-020-0708-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483244/
https://www.ncbi.nlm.nih.gov/pubmed/32161363
http://dx.doi.org/10.1038/s41380-020-0708-6

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