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Microglia phagocytose myelin sheaths to modify developmental myelination

During development, oligodendrocytes contact and wrap neuronal axons with myelin. Similar to neurons and synapses, excess myelin sheaths are produced and selectively eliminated, but how elimination occurs is unknown. Microglia, the resident immune cells of the CNS, engulf surplus neurons and synapse...

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Detalles Bibliográficos
Autores principales: Hughes, Alexandria N., Appel, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483351/
https://www.ncbi.nlm.nih.gov/pubmed/32632287
http://dx.doi.org/10.1038/s41593-020-0654-2