Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading

Ribosomes accurately decode mRNA by proofreading each aminoacyl-tRNA delivered by elongation factor EF-Tu(1). Understanding the molecular mechanism of proofreading requires visualizing GTP-catalyzed elongation, which has remained a challenge(2–4). Here, time-resolved cryo-EM revealed 33 states follo...

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Detalles Bibliográficos
Autores principales: Loveland, Anna B., Demo, Gabriel, Korostelev, Andrei A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483604/
https://www.ncbi.nlm.nih.gov/pubmed/32612237
http://dx.doi.org/10.1038/s41586-020-2447-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483604/
https://www.ncbi.nlm.nih.gov/pubmed/32612237
http://dx.doi.org/10.1038/s41586-020-2447-x

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