Membrane disruption, but not metabolic rewiring, is the key mechanism of anticancer-action of FASN-inhibitors: a multi-omics analysis in ovarian cancer

Fatty-acid(FA)-synthase(FASN) is a druggable lipogenic oncoprotein whose blockade causes metabolic disruption. Whether drug-induced metabolic perturbation is essential for anticancer drug-action, or is just a secondary—maybe even a defence response—is still unclear. To address this, SKOV3 and OVCAR3...

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Detalles Bibliográficos
Autores principales: Grunt, Thomas W., Slany, Astrid, Semkova, Mariya, Colomer, Ramón, López-Rodríguez, María Luz, Wuczkowski, Michael, Wagner, Renate, Gerner, Christopher, Stübiger, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483762/
https://www.ncbi.nlm.nih.gov/pubmed/32913236
http://dx.doi.org/10.1038/s41598-020-71491-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483762/
https://www.ncbi.nlm.nih.gov/pubmed/32913236
http://dx.doi.org/10.1038/s41598-020-71491-z

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