CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers

BRAF(V600E) is the most common genetic alteration and has become a major therapeutic target in thyroid cancers; however, intrinsic feedback mechanism limited clinical use of BRAF(V600E) specific inhibitors. Synthetic lethal is a kind of interaction between two genes, where only simultaneously pertur...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yiqi, Su, Xi, Feng, Chao, Liu, Siyu, Guan, Haixia, Sun, Yue, He, Nongyue, Ji, Meiju, Hou, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483764/
https://www.ncbi.nlm.nih.gov/pubmed/32913191
http://dx.doi.org/10.1038/s41392-020-00231-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483764/
https://www.ncbi.nlm.nih.gov/pubmed/32913191
http://dx.doi.org/10.1038/s41392-020-00231-6

Ejemplares similares