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CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers

BRAF(V600E) is the most common genetic alteration and has become a major therapeutic target in thyroid cancers; however, intrinsic feedback mechanism limited clinical use of BRAF(V600E) specific inhibitors. Synthetic lethal is a kind of interaction between two genes, where only simultaneously pertur...

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Detalles Bibliográficos
Autores principales:	Li, Yiqi, Su, Xi, Feng, Chao, Liu, Siyu, Guan, Haixia, Sun, Yue, He, Nongyue, Ji, Meiju, Hou, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483764/ https://www.ncbi.nlm.nih.gov/pubmed/32913191 http://dx.doi.org/10.1038/s41392-020-00231-6

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